L-Sulforaphane

L-Sulforaphane is an isothiocyanate derived from the natural compound glucoraphanin, which is abundant in cruciferous vegetables, including broccoli.¹ It has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects.^1,2 L-Sulforaphane, at 40 µM, activates nuclear factor erythroid 2-related factor 2- (Nrf2) mediated gene expression by disrupting its association with Kelch-like ECH-associated protein 1 (Keap1), allowing Nrf2 to enter the nucleus to alter transcription.^3,4 In this way, sulforaphane induces the expression of phase II detoxification enzymes, which in turn provide diverse beneficial effects.^5,1

WARNING This product is not for human or veterinary use.

1. James, D., Devaraj, S., Bellur, P., et al. Novel concepts of broccoli sulforaphanes and disease: Induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutr. Rev. 70(11), 654-665 (2012).

2. Liang, H., and Yuan, Q. Natural sulforaphane as a functional chemopreventive agent: Including a review of isolation, purification and analysis methods. Crit. Rev. Biotechnol. 32(3), 218-234 (2012).

3. La Marca, M., Beffy, P., Della Croce, C., et al. Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes. Food Chem. Toxicol. 50(8), 2822-2830 (2012).

4. Dinkova-Kostova, A.T., Holtzclaw, W.D., Cole, R.N., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. USA 99(18), 11908-11913 (2012).

5. Munday, R., and Munday, C.M. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds. J. Agric. Food. Chem. 52(7), 1867-1871 (2004).