An EP1 and EP3 receptor agonist
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17-phenyl trinor Prostaglandin E2

Item No. 14810

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-5-oxocyclopentyl]-5-heptenoic acid
CAS Number
38315-43-4
Synonyms
  • 17-phenyl trinor PGE2
Molecular Formula
C23H30O5
Formula Weight
386.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >0.8 mg/ml
SMILES
O[C@H]1[C@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@@H](C/C=C\CCCC(O)=O)C(C1)=O
InChi Code
InChI=1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1
InChi Key
FOBVMYJQWZOGGJ-XYRJXBATSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    17-phenyl trinor Prostaglandin E2 (17-phenyl trinor PGE2) is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.1,2 17-phenyl trinor PGE2 causes contraction of the guinea pig ileum at a concentration of 11 µM.1 It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.2 With an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lawrence, R.A., Jones, R.L., and Wilson, N.H. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br. J. Pharmacol. 105(2), 271-278 (1992).

    2. Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9(1), 9-18 (1975).