An ABHD6 inhibitor
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KT195

Item No. 14818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone
CAS Number
1402612-58-1
Synonyms
  • ML-295
Molecular Formula
C27H26N4O2
Formula Weight
438.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml
λmax
288 nm
SMILES
O=C(N1N=NC(C2=CC=C(C3=CC=C(OC)C=C3)C=C2)=C1)N4C(C5=CC=CC=C5)CCCC4
InChi Code
InChI=1S/C27H26N4O2/c1-33-24-16-14-21(15-17-24)20-10-12-22(13-11-20)25-19-31(29-28-25)27(32)30-18-6-5-9-26(30)23-7-3-2-4-8-23/h2-4,7-8,10-17,19,26H,5-6,9,18H2,1H3
InChi Key
OEHLNQDRVMDXQD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ.1,2 While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGLβ.1 By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells.1 KT195 is also reported to reduce IL-1β secretion from lipopolysaccharide-treated macrophages.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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