A serine protease inhibitor
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Nafamostat (mesylate)

Item No. 14837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(aminoiminomethyl)amino]-benzoic acid, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate
CAS Number
82956-11-4
Synonyms
  • Coahibitor
  • FUT 175
  • Nafamastat
Molecular Formula
C19H17N5O2 • 2CH3SO3H
Formula Weight
539.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
243 nm
SMILES
NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O.CS(=O)(O)=O
InChi Code
InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
InChi Key
SRXKIZXIRHMPFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease; Ki = 15 nM), tryptase (a mast cell protease; Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 μM).1 In a mouse model of allergic asthma, a dose of 300 mg/kg nafamostat mesylate has been shown to inhibit serine proteolytic activity, to decrease circulating levels of eosinophils and lymphocytes in bronchoalveolar lavage fluid, and to reduce interleukin-13 and eotaxin production associated with antigen-induced airway eosinophilia and goblet cell hyperplasia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mori, S., Itoh, Y., Shinohata, R., et al. Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J. Pharmacol. Sci. 92(4), 420-423 (2003).

    2. Ishizaki, M., Tanaka, H., Kajiwara, D., et al. Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. J. Pharmacol. Sci. 108(3), 355-363 (2008).