An inhibitor of lactate dehydrogenase
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Galloflavin

Item No. 14846

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,8,9,10-tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione
CAS Number
568-80-9
Synonyms
  • NSC 107022
Molecular Formula
C12H6O8
Formula Weight
278.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 12 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
259, 379, 397 nm
SMILES
O=C(O1)C(O)=CC2=C1C3=C(O)C(O)=C(O)C=C3C(O2)=O
InChi Code
InChI=1S/C12H6O8/c13-4-1-3-7(9(16)8(4)15)10-6(19-11(3)17)2-5(14)12(18)20-10/h1-2,13-16H
InChi Key
VYKVZHXHVUVABA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Galloflavin is an inhibitor of both the A and B isoforms of lactate dehydrogenase (Kis = 5.46 and 15.06 µM, respectively).1 It has been shown to prevent proliferation of many different cancer cell lines in vitro by blocking glycolysis and ATP production.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manerba, M., Vettraino, M., Fiume, L., et al. Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. Chem. Med. Chem. 7(2), (2012).

    2. Han, X., Sheng, X., Jones, H.M., et al. Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J. Hematol. Oncol. 8:2, (2015).