A selective Cdc42 inhibitor
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ZCL 278

Item No. 14849

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-acetamide
CAS Number
587841-73-4
Molecular Formula
C21H19BrClN5O4S2
Formula Weight
584.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/ml
λmax
257, 313 nm
SMILES
BrC1=CC(Cl)=C(OCC(NC(NC2=CC=C(S(NC3=NC(C)=CC(C)=N3)(=O)=O)C=C2)=S)=O)C=C1
InChi Code
InChI=1S/C21H19BrClN5O4S2/c1-12-9-13(2)25-20(24-12)28-34(30,31)16-6-4-15(5-7-16)26-21(33)27-19(29)11-32-18-8-3-14(22)10-17(18)23/h3-10H,11H2,1-2H3,(H,24,25,28)(H2,26,27,29,33)
InChi Key
XKZDWYDHEBCGCG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

    $176

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    Cayman Chemical
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    Product Description

    ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase.1 It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF).1 It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and neonatal cortical neurons, respectively.1 ZCL 278 also exhibits potent antiviral activity by inhibiting cellular entry of Junin virus (JUNV) and other enveloped viruses into cells and inhibiting viral replication in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Friesland, A., Zhao, Y., Chen, Y.-H., et al. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc. Natl. Acad. Sci. USA 110(4), 1261-1266 (2016).

    2. Chou, Y.-y., Cuevas, C., Carocci, M., et al. Identification and characterization of a novel broad-spectrum virus entry inhibitor. J. Virol. 90(9), 4494-4510 (2016).