A photoactivatable TRPA1 ligand
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Optovin

Item No. 14851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone
CAS Number
348575-88-2
Molecular Formula
C15H13N3OS2
Formula Weight
315.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:6): 0.14 mg/mlDMSO: 20 mg/ml
λmax
290, 420 nm
SMILES
CC1=CC(/C=C2SC(N([H])C/2=O)=S)=C(C)N1C3=CN=CC=C3
InChi Code
InChI=1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)/b13-7+
InChi Key
YISGMOZSGOGYOU-NTUHNPAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $349

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    50 mg

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    Product Description

    Optovin is a TRPA1 ligand that can be reversibly photoactivated by violet (405 nm) light.1 Optovin-treated zebrafish respond to light with vigorous motor excitation (EC50 = 2 µM).1 Optovin-treated mouse dorsal root ganglia neurons displayed increased intracellular calcium following stimulation with light but only in wild-type TRPA1 cells.1 Optovin has been used to study the role of TRPA1 in the response of cardiac myocytes to reperfusion injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kokel, D., Cheung, C.Y.J., Mills, R., et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat. Chem. Biol. 9(4), 257-263 (2013).

    2. Lu, Y., Piplani, H., McAllister, S.L., et al. Transient receptor potential ankyrin 1 activation within the cardiac myocyte limits ischemia-reperfusion injury in rodents. Anesthesiology 125(6), 1171-1180 (2016).