An allosteric activator of CD11b/CD18
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Leukadherin 1

Item No. 14855

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid
CAS Number
344897-95-6
Molecular Formula
C22H15NO4S2
Formula Weight
421.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
λmax
312, 449 nm
SMILES
O=C(/C(SC1=S)=C/C2=CC=C(C3=CC=C(C(O)=O)C=C3)O2)N1CC4=CC=CC=C4
InChi Code
InChI=1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
InChi Key
AEZGRQSLKVNPCI-UNOMPAQXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Leukadherin 1 is a small molecule allosteric activator of CD11b/CD18 that increases K562 cell adhesion to an endogenous CD11b/CD18 ligand, fibrinogen (EC50 = 4 µM).1 It increases adhesion and decreases de-adhesion of murine neutrophils, leading to reduced chemotaxis. It acts by reducing the rolling velocity of leukocytes in mouse cremaster muscle, decreasing the number of leukocytes recruited to injured tissue. Leukadherin 1 is anti-inflammatory in a zebrafish tailfin injury model and a mouse model of anti-glomerular basement membrane nephritis. It also competitively inhibits YopH (Ki = 1.94 µM), a tyrosine phosphorylase secreted by Y. pestis into immune cells to block signal transduction, and anthrax lethal factor metalloproteinase, a component of anthrax toxin (IC50 = 6 µM).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maiguel, D., Faridi, M.H., Wei, C., et al. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci. Signal 4(189), ra57 (2011).

    2. Tautz, L., Bruckner, S., Sareth, S., et al. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. The Journal of Biological Chemisty 280(10), 9400-9408 (2005).

    3. Forino, M., Johnson, S., Wong, T.Y., et al. Efficient synthetic inhibitors of anthrax lethal factor. Proc. Natl. Acad. Sci. USA 102(27), 9499-9504 (2005).