An antagonist of NR2C- and NR2D-subunit containing NMDA receptors
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QNZ 46

Item No. 14857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[6-methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic acid
CAS Number
1237744-13-6
Molecular Formula
C24H17N3O6
Formula Weight
443.4
Purity
≥98%
Formulation
A crystalline solid
λmax
228, 346 nm
SMILES
O=C1C2=CC(OC)=CC=C2N=C(/C=C/C3=CC([N+]([O-])=O)=CC=C3)N1C4=CC=C(C(O)=O)C=C4
InChi Code
InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
InChi Key
GNLVJIICVWDSNI-LFYBBSHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $124

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    10 mg

    $207

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    Product Description

    QNZ 46 is an antagonist of NR2C- and NR2D-subunit containing NMDA receptors (IC50s = 6 and 3 µM, respectively, for receptors expressed in Xenopus oocytes).1 It is selective for NR2C- and NR2D-subunit containing NMDA receptors over receptors containing NR2A and NR2B subunits as well as over the AMPA receptor GluR1 (IC50s = 229, >300, and >300 µM, respectively). QNZ 46 acts in a noncompetitive and voltage-independent fashion that requires glutamate but not glycine binding for its activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mosley, C.A., Acker, T.M., Hansen, K.B., et al. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J. Med. Chem. 53(15), 5476-5490 (2010).

    2. Hansen, K.B., and Traynelis, S.F. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J. Neurosci. 31(10), 3650-3661 (2011).