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NSC 405020

Item No. 14859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dichloro-N-(1-methylbutyl)-benzamide
CAS Number
7497-07-6
Molecular Formula
C12H15Cl2NO
Formula Weight
260.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
238 nm
SMILES
ClC1=CC(C(N([H])C(C)CCC)=O)=CC=C1Cl
InChi Code
InChI=1S/C12H15Cl2NO/c1-3-4-8(2)15-12(16)9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
InChi Key
ARDYECYBETXQFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

    $236

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    Cayman Chemical
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    Product Description

    NSC 405020 binds to the hemopexin (PEX) domain of the membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14).1 It disrupts MT1-MMP homodimerization without affecting its catalytic activity in an assay using the MT1-MMP CAT domain, which is involved in its tumor promoting function (IC50 > 100 µM). In a mouse tumor xenograft model, it reduces tumor growth through a cell death-independent mechanism when injected intratumorally at a dose of 0.5 mg/kg three times per week for two weeks. NSC 405020 (1 µM) applied to HSC5 cells prevents arsenic-mediated invasion while also decreasing the expression of MT1-MMP and pERK.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Remacle, A.G., Golubkov, V.S., Shiryaev, S.A., et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72(9), 2339-2349 (2012).

    2. Thang, N.D., Yajima, I., Kumasaka, M.Y., et al. Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma. PLoS One 9(5), e96945 (2014).