A selective inhibitor of Akt
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Akt Inhibitor X

Item No. 14863

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N,N-diethyl-10H-phenoxazine-10-butanamine, monohydrochloride
CAS Number
925681-41-0
Synonyms
  • 10-DEBC
Molecular Formula
C20H25ClN2O • HCl
Formula Weight
381.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 12.5 mg/mlEthanol: 16 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
242, 333 nm
SMILES
ClC1=CC2=C(C=C1)OC3=CC=CC=C3N2CCCCN(CC)CC.Cl
InChi Code
InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
InChi Key
SVKSJUIYYCQZEC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $57

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM.1 This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM.1 Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thimmaiah, K.N., Easton, J.B., Germain, G.S., et al. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. The Journal of Biological Chemisty 280(36), 31924-31935 (2005).