A Bcl-2 inhibitor
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HA-14-1

Item No. 14876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,4R)-rel-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester
CAS Number
927635-64-1
Molecular Formula
C17H17BrN2O5
Formula Weight
409.2
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 16 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
λmax
230, 274 nm
SMILES
NC1=C(C(OCC)=O)C(C(C#N)C(OCC)=O)C2=CC(Br)=CC=C2O1
InChi Code
InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChi Key
SXJDCULZDFWMJC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $153

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    50 mg

    $219

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    Cayman Chemical
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    Product Description

    HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.1 It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W.2 HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, J.L., Liu, D., Zhang, Z.J., et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. USA 97(13), 7124-7129 (2000).

    2. Azmi, A.S., and Mohammad, R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J. Cell Physiol. 218(1), 13-21 (2009).