A purine antimetabolite and an ADA inhibitor
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Pentostatin

Item No. 14878

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
CAS Number
53910-25-1
Synonyms
  • CI 825
  • CL 67310465
  • DCF
  • 2′-Deoxycoformycin
  • Deoxycoformycin
  • NSC 218321
  • NSC 247520
Molecular Formula
C11H16N4O4
Formula Weight
268.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
286 nm
SMILES
OC[C@@H]1[C@@H](O)C[C@H](N2C=NC3=C2NC=NC[C@H]3O)O1
InChi Code
InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChi Key
FPVKHBSQESCIEP-JQCXWYLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Pentostatin is a purine antimetabolite and an adenosine deaminase (ADA) inhibitor (Ki = 0.09 nM).1,2 It reduces 2'-deoxyadenosine-induced growth inhibition of MOLT-4 lymphoblast cells (Ki = 5.6 µM). It inhibits erythrocyte and ascites tumor cell ADA in an L1210 murine skin lymphocytic leukemia model when administered at a dose of 0.2 mg/kg.3 Pentostatin (10 µg/animal) inhibits tumor growth and increases survival rate in a CT26/NY-ESO-1 mouse xenograft model.2 Formulations containing pentostatin have been used in the treatment of hairy cell leukemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shewach, D.S., Krawczyk, S.H., Acevedo, O.L., et al. Inhibition of adenosine deaminase by azapurine ribonucleosides. Biochem. Pharmacol. 44(9), 1697-1700 (1992).

    2. Tusup, M., Kündig, T.M., and Pascolo, S. Epitranscriptomics modifier pentostatin indirectly triggers Toll-like receptor 3 and can enhance immune infiltration in tumors. Mol. Ther. 30(3), 1163-1170 (2022).

    3. Agarwal, R.P. Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivo. Cancer Res. 39(4), 1425-1427 (1979).