An inhibitor of tissue transglutaminase
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Labeled Version(s)
26775Cystamine-d8 (hydrochloride)
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Cystamine (hydrochloride)

Item No. 14882

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2'-dithiobis-ethanamine, dihydrochloride
CAS Number
56-17-7
Molecular Formula
C4H12N2S2 • 2HCl
Formula Weight
225.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NCCSSCCN.Cl.Cl
InChi Code
InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H
InChi Key
YUFRRMZSSPQMOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 g

    $28

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    50 g

    $53

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    100 g

    $94

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    500 g

    $303

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    Product Description

    Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM.1 It is orally available and is neuroprotective in mouse models of Huntington’s disease.2,3 Cystamine also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smethurst, P.A., and Griffin, M. Measurement of tissue transglutaminase activity in a permeabilized cell system: Its regulation by Ca2+ and nucleotides. Biochem. J. 313(pt 3), 803-808 (1996).

    2. Dedeoglou, A., Kubilus, J.K., Jeitner, T.M., et al. Therapeutic effects of cystamine in a murine model of Huntington’s disease. J. Neurosci. 22(20), 8942-8950 (2002).

    3. Borrell-Pagès, M., Canals, K.P., Cordelièrs, F.P., et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J. Clin. Invest. 116(5), 1410-1424 (2006).

    4. Elli, L., Ciulla, M.M., Busca, G., et al. Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease. Lab. Invest. 91(3), 452-461 (2011).