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JWH 018 8-quinolinyl carboxamide

Item No. 14891

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-pentyl-N-8-quinolinyl-1H-indole-3-carboxamide
CAS Number
1400742-39-3
Molecular Formula
C23H23N3O
Formula Weight
357.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16.6 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 0.16 mg/ml
λmax
219, 245, 307, 332 nm
SMILES
O=C(NC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCC)C4=C3C=CC=C4
InChi Code
InChI=1S/C23H23N3O/c1-2-3-6-15-26-16-19(18-11-4-5-13-21(18)26)23(27)25-20-12-7-9-17-10-8-14-24-22(17)20/h4-5,7-14,16H,2-3,6,15H2,1H3,(H,25,27)
InChi Key
LSDZETPTKCENTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 018 (Item No. 10900) is a synthetic cannabinoid (CB) that potently activates both the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends.2,3,4 Structurally, JWH 018 is an alkylindole joined to a naphthyl group by methanone. JWH 018 8-quinolinyl carboxamide (Item No. 14891) is a structural analog of JWH 018 in which the naphthalenyl methanone portion has been replaced by 8-quinolinyl carboxamide. The physiological and toxicological properties of this compound have not been investigated. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60(2), 133-140 (2000).

    2. Auwärter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5), 832-837 (2009).

    3. Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci. Int. 191(1-3), 58-63 (2009).

    4. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol. 27(2), 61-66 (2009).