A potent inhibitor of SHP-1 and SHP-2
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NSC 87877

Item No. 14908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-hydroxy-7-[2-(6-sulfo-2-naphthalenyl)diazenyl]-5-quinolinesulfonic acid
CAS Number
56990-57-9
Molecular Formula
C19H13N3O7S2
Formula Weight
459.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
220, 341, 534 nm
SMILES
OS(C(C=C1)=CC(C1=C2)=CC=C2/N=N/C3=C(O)C4=NC=CC=C4C(S(O)(=O)=O)=C3)(=O)=O
InChi Code
InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,23H,(H,24,25,26)(H,27,28,29)/b22-21+
InChi Key
XGMFVZOKHBRUTL-QURGRASLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $42

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    25 mg

    $87

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    50 mg

    $143

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    100 mg

    $242

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    Product Description

    The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction.1 NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively).1 It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26.1,2 Through its effects on SHP-1 or SHP-2, NSC 87877 blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes.1,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, L., Sung, S.S., Yip, M.L.R., et al. Discovery of a novel Shp2 protein tyrosine phosphatase inhibitor. Mol. Pharmacol. 70(2), 562-570 (2006).

    2. Song, M., Park, J.E., Park, S.G., et al. NSC-87877, inhibitor of SHP-½ PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem. Biophys. Res. Commun. 381(4), 491-495 (2009).

    3. Redondo, P.C., Harper, A.G.S., Harper, M.T., et al. hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J. Thromb. Haemost. 5(12), 2478-2483 (2007).

    4. Zhao, X.T., Qian, Y.K., Chan, A.W.S., et al. Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev. Neurobiol. 67(13), 1789-1801 (2007).