A selective EP2 receptor agonist
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19(R)-hydroxy Prostaglandin E2

Item No. 14910

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,15S,19R-trihydroxy-9-oxo-prosta-5Z,13E-dien-1-oic acid
CAS Number
64625-54-3
Synonyms
  • 19(R)-hydroxy PGE2
  • 19(R)-OH PGE2
Molecular Formula
C20H32O6
Formula Weight
368.5
Purity
≥98%
Formulation
A 500 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): >5 mg/ml
SMILES
O[C@H]1[C@H](/C=C/[C@@H](O)CCC[C@H](O)C)[C@@H](C/C=C\CCCC(O)=O)C(C1)=O
InChi Code
InChI=1S/C20H32O6/c1-14(21)7-6-8-15(22)11-12-17-16(18(23)13-19(17)24)9-4-2-3-5-10-20(25)26/h2,4,11-12,14-17,19,21-22,24H,3,5-10,13H2,1H3,(H,25,26)/b4-2-,12-11+/t14-,15+,16-,17-,19-/m1/s1
InChi Key
WTJYDBMHYPQFNJ-ZUVVJKHESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $62

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    100 µg

    $116

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    500 µg

    $472

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    1 mg

    $823

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    Product Description

    19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man.1 It is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor.1,2 It has an EC50 value of 200 nM for relaxing cat tracheal rings which express EP2 receptors.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kelly, R.W., Taylor, P.L., Hearn, J.P., et al. 19-Hydroxyprostaglandin E1 as a major component of the semen of primates. Nature 260(5551), 544-545 (1976).

    2. Woodward, D.F., Protzman, C.E., Krauss, A.H.P., et al. Identification of 19(R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. Prostaglandins 46(4), 371-383 (1993).