A natural antiviral and anti-fibrosis alkaloid
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Oxymatrine

Item No. 14915

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R,7aS,13aR,13bR,13cS)-dodecahydro-4-oxide-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
CAS Number
16837-52-8
Synonyms
  • Matrine 1-oxide
Molecular Formula
C15H24N2O2
Formula Weight
264.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 33.3 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C1N2[C@@](CCC1)([H])[C@]3([H])[C@@]4([H])[N+](CCC[C@@]4([H])C2)([O-])CCC3
InChi Code
InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1
InChi Key
XVPBINOPNYFXID-LHDUFFHYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $54

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    100 mg

    $91

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    500 mg

    $185

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    1 g

    $262

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    Cayman Chemical
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    Product Description

    Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine.1 It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine.2,3 Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling.4,5 This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB.1,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ling, Q., Xu, X., Wei, X., et al. Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J. Exp. Clin. Cancer Res. 30, 66 (2011).

    2. Cui, X., Wang, Y., Kokudo, N., et al. Traditional Chinese medicine and related active compounds against hepatitis B virus infection. Biosci. Trends 4(2), 39-47 (2010).

    3. Ma, Z.J., Li, Q., Wang, J.B., et al. Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the hepatitis B virus in vitro. Evid. Based Complement. Alternat. Med. 2013, 186573 (2013).

    4. Chai, N.L., Fu, Q., Shi, H., et al. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World J. Gastroenterol. 18(31), 4199-4206 (2012).

    5. Wu, X.L., Zeng, W.Z., Jiang, M.D., et al. Effect of oxymatrine on the TGβSmad signaling pathway in rats with CCl4-induced hepatic fibrosis. World J. Gastroenterol. 14(13), 2100-2105 (2008).

    6. Guzman, J.R., Koo, J.S., Goldsmith, J.R., et al. Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation. Sci. Rep. 3, 1629 (2013).