A selective inhibitor of neutrophil elastase
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Neutrophil Elastase Inhibitor

Item No. 14922

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3-methylbenzoyl)-1H-indazole-3-carbonitrile
CAS Number
1448314-31-5
Molecular Formula
C16H11N3O
Formula Weight
261.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/ml
λmax
242, 307 nm
SMILES
O=C(C1=CC=CC(C)=C1)N2C3=CC=CC=C3C(C#N)=N2
InChi Code
InChI=1S/C16H11N3O/c1-11-5-4-6-12(9-11)16(20)19-15-8-3-2-7-13(15)14(10-17)18-19/h2-9H,1H3
InChi Key
KRFSMLDUZFVINX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

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    25 mg

    $297

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    50 mg

    $525

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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase plays a critical role in degrading invading pathogens and thus provides the earliest line of defense in the immune system. Neutrophil elastase inhibitor is an N-benzoylindazole derivative that selectively targets the binding domain of neutrophil elastase (IC50 = 7 nM).1 It has been shown to inhibit additional serine proteases, thrombin and urokinase, only at higher, micromolar concentrations (IC50s = 1.9 and 6.6 µM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crocetti, L., Schepetkin, I.A., Cilibrizzi, A., et al. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. J. Med. Chem. 56(15), 6259-6272 (2013).