An AMPA receptor modulator
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CX-516

Item No. 14936

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-piperidinyl-6-quinoxalinyl-methanone
CAS Number
154235-83-3
Synonyms
  • Ampalex
  • BDP-12
  • Benzoyl-Piperidine-12
Molecular Formula
C14H15N3O
Formula Weight
241.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
203, 237, 319 nm
SMILES
O=C(C1=CC(N=CC=N2)=C2C=C1)N3CCCCC3
InChi Code
InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
InChi Key
ANDGGVOPIJEHOF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $105

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    25 mg

    $220

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    50 mg

    $414

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    Product Description

    CX-516 is an AMPA receptor modulator.1,2 It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, CX-516 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner.2 It enhances performance in a spatial, delayed nonmatch-to-sample (DNMS) test in rats.3 CX-516 also reverses dominance between initially dominant and submissive rat pairs, a marker of antidepressant-like activity, in the rat reduction of submissive behavior model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sirvio, J., Larson, J., Quach, C.N., et al. Effects of pharmacologically facilitating glutamatergic transmission in the trisynaptic intrahippocampal circuit. Neuroscience 74(4), 1025-1035 (1996).

    2. Rogan, M.T., Stäubli, U.V., and LeDoux, J.E. AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired. J. Neurosci. 17(15), 5928-5935 (1997).

    3. Hampson, R.E., Rogers, G., Lynch, G., et al. Facilitative effects of the ampakine CX516 on short-term memory in rats: Enhancement of delayed-nonmatch-to-sample performance. J. Neurosci. 18(7), 2740-2747 (1998).

    4. Knapp, R.J., Goldenberg, R., Shuck, C., et al. Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. Eur. J. Pharmacol. 440(1), 27-35 (2002).