An active metabolite of tryptophan and an NMDA receptor agonist
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Quinolinic Acid

Item No. 14941

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-pyridinedicarboxylic acid
CAS Number
89-00-9
Synonyms
  • NSC 13127
  • NSC 18836
  • NSC 403247
Molecular Formula
C7H5NO4
Formula Weight
167.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 16 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
216, 264 nm
SMILES
O=C(O)C1=CC=CN=C1C(O)=O
InChi Code
InChI=1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChi Key
GJAWHXHKYYXBSV-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    10 g

    $53

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    50 g

    $169

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    Product Description

    Quinolinic acid is an active metabolite of tryptophan (Item Nos. 29600 | 31210) and an NMDA receptor agonist.1,2 It is formed from tryptophan via the kynurenine pathway.1 Quinolinic acid (100 µM) induces lipid peroxidation in rat brain synaptosomes, an effect that can be reversed by the NMDA receptor antagonist 2-amino-5-phosphonovaleric acid.3 It decreases the viability of primary rat neurons when used at a concentration of 25 µM.4 Intracerebroventricular administration of quinolinic acid (1 µg/animal) induces convulsions in mice.5 Increased plasma levels of quinolinic acid negatively correlate with Brief Neurocognitive Assessment (BNA) scores in patients with schizophrenia.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heyes, M.P., Achim, C.L., Wiley, C.A., et al. Human microglia convert L-tryptophan into the neurotoxin quinolinic acid. Biochem. J. 320(2), 595-597 (1996).

    2. Stone, T.W., and Perkins, M.N. Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS. Eur. J. Pharmacol. 72(4), 411-412 (1981).

    3. Carpenedo, R., Meli, E., Peruginelli, F., et al. Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures. J. Neurochem. 82(6), 1465-1471 (2002).

    4. Lisak, R.P., Nedelkoska, L., Bealmear, B., et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp. Neurol. 273, 161-167 (2015).

    5. Lapin, I.P. Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J. Neural. Transm. 42(1), 37-43 (1978).

    6. Cathomas, F., Guetter, K., Seifritz, E., et al. Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder. Sci. Rep. 11(1), 9992 (2021).