A metabolite of 20-HETE and PGE2
Related Products
Parent Compound(s)
9003020-HETE 14010Prostaglandin E2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

20-hydroxy Prostaglandin E2

Item No. 14950

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-11α,15S,20-trihydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number
57930-95-7
Synonyms
  • 20-hydroxy PGE2
  • 20-OH PGE2
Molecular Formula
C20H32O6
Formula Weight
368.5
Purity
≥95%
Formulation
A 500 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/ml (from PGE2)DMSO: >100 mg/ml (from PGE2)Ethanol: >100 mg/ml (from PGE2)PBS pH 7.2: >5 mg/ml (from PGE2)
SMILES
O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCCO)[C@H](O)C1
InChi Code
InChI=1S/C20H32O6/c21-13-7-3-4-8-15(22)11-12-17-16(18(23)14-19(17)24)9-5-1-2-6-10-20(25)26/h1,5,11-12,15-17,19,21-22,24H,2-4,6-10,13-14H2,(H,25,26)/b5-1-,12-11+/t15-,16+,17+,19+/m0/s1
InChi Key
AZIGEYVZEVXWAD-NZGURKHLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 µg

    $70

    Add

    100 µg

    $129

    Add

    500 µg

    $535

    Add

    1 mg

    $934

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    20-hydroxy Prostaglandin E2 (PGE2) is a metabolite of 20-HETE (Item No. 90030) and PGE2 (Item No. 14010).1,2 It inhibits IFN-γ-induced kynurenine production in THP-1 cells and primary human monocytes (IC50s = 7.4 and 11.2 µM, respectively).3 20-hydroxy PGE2 (1 µM) induces lipid accumulation and lipid droplet formation in primary human mesenchymal stem cell-derived adipocytes.4 Intra-arterial infusion of 20-hydroxy PGE2 increases cortical and medullary blood flow in rat kidneys.5 Serum levels of 20-hydroxy PGE2 are decreased in patients with rheumatoid arthritis.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. Am. J. Physiol. 277(3), R607-R623 (1999).

    2. Oliw, E.H., Fahlstadius, P., and Hamberg, M. Isolation and biosynthesis of 20-hydroxyprostaglandins E1 and E2 in ram seminal fluid. The Journal of Biological Chemisty 261, 9216-9221 (1986).

    3. Costabile, M., Bassal, N.K., Gerber, J.P., et al. Inhibition of indoleamine 2,3-dioxygenase activity by fatty acids and prostaglandins: A structure function analysis. Prostaglandins Leukot. Essent. Fatty Acids 122, 7-15 (2017).

    4. Kim, D.H., Puri, N., Sodhi, K., et al. Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J. Lipid Res. 54(3), 786-793 (2013).

    5. Oyekan, A.O. Differential effects of 20-hydroxyeicosatetraenoic acid on intrarenal blood flow in the rat. J Pharmacol Exp Ther. 313(3), 1289-1295 (2005).

    6. Rodríguez-Carrio, J., Coras, R., Alperi-López, M., et al. Profiling of serum oxylipins during the earliest stages of rheumatoid arthritis. Arthritis Rheumatol. 73(3), 401-413 (2021).

    Product Citations

    Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018).