A plant lectin with diverse biological activities
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Concanavalin A

Item No. 14951

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
11028-71-0
Synonyms
  • Con A
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
Origin
Plant/Canavalia ensiformis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $46

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    100 mg

    $63

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    250 mg

    $135

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    Cayman Chemical
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    Product Description

    Concanavalin A is a plant lectin that has been found in jack bean (C. ensiformis) and is involved in plant defense.1 It is formed from the 290-amino acid precursor protein pro-concanavalin A via deglycosylation by N-glycanase, peptide cleavage, and re-ligation to form the mature 237-amino acid monomer, which oligomerizes to form a tetramer. Each concanavalin A monomer has a carbohydrate recognition domain, which binds to α-D-mannose, α-D-glucose, and β-D-fructose, and a metal binding site that is involved in stability.1,2 Concanavalin A has diverse biological activities, including erythrocyte agglutination, mitogenic stimulation, and anticancer activity.1,2,3 It has been used in affinity purification of various glycoproteins, as well as to induce T cell activation in vitro and liver injury in experimental mouse models of autoimmune hepatitis.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suvarna, G., and Sharma, B.B. Concanavalin - A potential glycoprotein. J. Proteins Proteomics 9(2), 77-90 (2018).

    2. Huldani, H., Rashid, A.I., Turaev, K.N., et al. Concanavalin A as a promising lectin-based anti-cancer agent: The molecular mechanisms and therapeutic potential. Cell Commun. Signal. 20(1), 167 (2022).

    3. Liu, B., Min, M.W., and Bao, J.K. Induction of apoptosis by concanavalin A and its molecular mechanisms in cancer cells. Autophagy 5(3), 432-433 (2009).

    4. Wang, L., Li, F., Sun, W., et al. Concanavalin A-captured glycoproteins in healthy human urine. Mol. Cell. Proteomics 5(3), 560-562 (2006).

    5. Dwyer, J.M., and Johnson, C. The use of concanavalin A to study the immunoregulation of human T cells. Clin. Exp. Immunol. 46(2), 237-249 (1981).

    6. Wang, H.X., Liu, M., Weng, S.Y., et al. Immune mechanisms of concanavalin A model of autoimmune hepatitis. World J. Gastroenterol. 18(2), 119-125 (2012).