A proprotein convertase inhibitor
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Furin Inhibitor I (trifluoroacetate salt)

Item No. 14965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide, trifluoroacetate salt
Synonyms
  • Decanoyl-Arg-Val-Lys-Arg-CMK
Molecular Formula
C34H66ClN11O5 • XCF3COOH
Formula Weight
744.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlEthanol: 33 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCC)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)N[C@@H](CCCNC(N)=N)C(CCl)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C34H66ClN11O5.C2HF3O2/c1-4-5-6-7-8-9-10-18-28(48)43-25(17-14-21-42-34(39)40)31(50)46-29(23(2)3)32(51)45-26(15-11-12-19-36)30(49)44-24(27(47)22-35)16-13-20-41-33(37)38;3-2(4,5)1(6)7/h23-26,29H,4-22,36H2,1-3H3,(H,43,48)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42);(H,6,7)/t24-,25-,26-,29-;/m0./s1
InChi Key
QYMXBIIZDOWKAX-AZRYXFGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $103

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    1 mg

    $173

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    5 mg

    $801

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    Product Description

    Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).1,2 Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.3 In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Angliker, H., Wikstrom, P., Shaw, E., et al. The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. Biochem. J. 293(1), 75-81 (1993).

    2. Fugère, M., Limperis, P.C., Beaulieu-Audy, V., et al. Inhibitory potency and specificity of subtilase-like Pro-protein convertase (SPC) prodomains. The Journal of Biological Chemisty 277(10), 7648-7656 (2002).

    3. Wanyiri, J.W., O'Connor, R., Allison, G., et al. Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity. Infect. Immun. 75(1), 184-192 (2007).

    4. Stawowy, P., Meyborg, H., Stibenz, D., et al. Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis. Circulation 111(21), 2820-2827 (2005).