An irreversible inhibitor of serine proteases
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p-APMSF (hydrochloride)

Item No. 14971

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(aminoiminomethyl)-benzenemethanesulfonyl fluoride, monohydrochloride
CAS Number
74938-88-8
Synonyms
  • (p-Amidinophenyl)methanesulfonyl Fluoride
  • para-APMSF
Molecular Formula
C8H9FN2O2S • HCl
Formula Weight
252.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/mLWater: 25 mg/mL
λmax
232 nm
SMILES
FS(CC1=CC=C(C(N)=N)C=C1)(=O)=O.Cl
InChi Code
InChI=1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
InChi Key
KHLLRHIUKOJXLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $37

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    5 mg

    $98

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    10 mg

    $176

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    25 mg

    $392

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    Product Description

    p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 µM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively.1 It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laura, R., Robison, D.J., and Bing, D.H. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases. Biochemistry 19(21), 4859-4864 (1980).