A β4 subunit-selective nAChR agonist
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SIB 1553A (hydrochloride)

Item No. 14973

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]-phenol, monohydrochloride
CAS Number
191611-89-9
Molecular Formula
C13H19NOS • HCl
Formula Weight
273.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
229, 255 nm
SMILES
OC1=CC=C(SCCC2CCCN2C)C=C1.Cl
InChi Code
InChI=1S/C13H19NOS.ClH/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13;/h4-7,11,15H,2-3,8-10H2,1H3;1H
InChi Key
RJSVKPQKXSMZMT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $202

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    50 mg

    $797

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    Product Description

    SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors.1 Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bontempi, B., Whelan, K.T., Risbrough, V.B., et al. SIB-1553A, (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: Effects on working and reference memory performances in aged rodents and nonhuman primates. J. Pharmacol. Exp. Ther. 299(1), 297-306 (2001).

    2. Schneider, J.S., Tinker, J.P., Menzaghi, F., et al. The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. J. Pharmacol. Exp. Ther. 306(1), 401-406 (2003).

    3. Terry, A.V., Jr., Risbrough, V.B., Buccafusco, J.J., et al. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys. J. Pharmacol. Exp. Ther. 301(1), 284-292 (2002).