A caspase-10 inhibitor
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Z-AEVD-FMK

Item No. 14987

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
methyl-14S-(2-fluoroacetyl)-11S-isopropyl-8S-(3-methoxy-3-oxopropyl)-5S-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
CAS Number
1135688-47-9
Synonyms
  • Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
Molecular Formula
C28H39FN4O10
Formula Weight
610.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml*
SMILES
C[C@H](NC(OCC1=CC=CC=C1)=O)C(N[C@@H](CCC(OC)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(OC)=O)C(CF)=O)=O)=O)=O
InChi Code
InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1
InChi Key
CHZRBQFKZDGMTP-CDSYHYPYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $143

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    5 mg

    $627

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    Product Description

    Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.1 At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, S.J., Wu, C.H., Gordon, J.D., et al. Taxol induces caspase-10-dependent apoptosis. The Journal of Biological Chemisty 279(49), 51057-51067 (2004).

    2. Milhas, D., Cuvillier, O., Therville, N., et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. The Journal of Biological Chemisty 280(20), 19836-19842 (2005).