A caspase-8 fluorogenic substrate
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Ac-LETD-AFC

Item No. 14991

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine
CAS Number
210345-02-1
Synonyms
  • N-Acetyl-Leu-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin
  • Caspase-8 Substrate (Fluorogenic)
Molecular Formula
C31H38F3N5O12
Formula Weight
729.7
Purity
≥95%
Emission
505 nm
Excitation
400 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
206, 339 nm
SMILES
OC(C[C@H](NC(C(NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)C(NC(C=C1O2)=CC=C1C(C(F)(F)F)=CC2=O)=O)=O
InChi Code
InChI=1S/C31H38F3N5O12/c1-13(2)9-20(35-15(4)41)29(49)37-19(7-8-23(42)43)27(47)39-26(14(3)40)30(50)38-21(12-24(44)45)28(48)36-16-5-6-17-18(31(32,33)34)11-25(46)51-22(17)10-16/h5-6,10-11,13-14,19-21,26,40H,7-9,12H2,1-4H3,(H,35,41)(H,36,48)(H,37,49)(H,3
InChi Key
KTZOWCXXAYFIFT-XSSXFGQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $70

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    5 mg

    $137

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    10 mg

    $240

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    Product Description

    Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

    WARNING This product is not for human or veterinary use.