STA-21

STA-21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM.¹ It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC₅₀ = 12.2 μM).^1,2,3 STAT3 inhibitors, including STA-21, prevent the proliferation of human keratinocytes and have value in improving psoriasis.⁴

WARNING This product is not for human or veterinary use.

1. Song, H., Wang, R., Wang, S., et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. USA 102(13), 4700-4705 (2005).

2. Bhasin, D., Cisek, K., Pandharkar, T., et al. Design, synthesis, and studies of small molecule STAT3 inhibitors. Bioorg. Med. Chem. Lett. 18(1), 391-395 (2008).

3. Chen, C.L., Loy, A., Cen, L., et al. Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. BMC Cancer 7, 111 (2007).

4. Miyoshi, K., Takaishi, M., Nakajima, K., et al. Stat3 as a therapeutic target for the treatment of psoriasis: A clinical feasibility study with STA-21, a Stat3 inhibitor. J. Invest. Dermatol. 131(1), 108-117 (2011).