An irreversible inhibitor of aromatase
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Active Metabolite(s)
2798917β-hydroxy Exemestane
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Exemestane

Item No. 15008

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methylene-androsta-1,4-diene-3,17-dione
CAS Number
107868-30-4
Synonyms
  • FCE 24304
Molecular Formula
C20H24O2
Formula Weight
296.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
246 nm
SMILES
O=C1CC[C@@]2([H])[C@]3([H])CC(C4=CC(C=C[C@]4(C)[C@@]3([H])CC[C@@]21C)=O)=C
InChi Code
InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
InChi Key
BFYIZQONLCFLEV-DAELLWKTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Product Description

    Exemestane is an irreversible inhibitor of aromatase (Ki = 26 nM).1 It is selective for aromatase over 5α-reductase when used at a concentration of 30 µM. Subcutaneous administration of exemestane (3-100 mg/kg per day) decreases tumor proliferation in rats with mammary tumors induced by the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA; Item No. 30383).2 Formulations containing exemestane have been used in the treatment of estrogen receptor-positive breast cancers in postmenopausal women.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giudici, D., Ornati, G., Briatico, G., et al. 6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irreversible aromatase inhibitor. J. Steroid Biochem. 30(1-6), 391-394 (1988).

    2. Zaccheo, T., Giudici, D., Lombardi, P., et al. A new irreversible aromatase inhibitor, 6-methylenandrosta-1,4-diene-3,17-dione (FCE 24304): Antitumor activity and endocrine effects in rats with DMBA-induced mammary tumors. Cancer Chemother. Pharmacol. 23(1), 47-50 (1989).