A class III antiarrhythmic drug
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(±)-Ibutilide (hemifumarate)

Item No. 15011

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1)
CAS Number
122647-32-9
Synonyms
  • U-70226E
Molecular Formula
C20H36N2O3S • 1/2C4H4O4
Formula Weight
442.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
229 nm
SMILES
CS(NC1=CC=C(C(O)CCCN(CC)CCCCCCC)C=C1)(=O)=O.O=C(O)/C=C/C(O)=O
InChi Code
InChI=1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChi Key
PCIOHQNIRPWFMV-WXXKFALUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    50 mg

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    100 mg

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    250 mg

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    Product Description

    (±)-Ibutilide is a class III antiarrhythmic agent.1 It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM.2 (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular cells.3 It decreases ventricular fibrillation induced by the ATP-dependent potassium channel activator pinacidil (Item No. 15416) in Langendorff isolated perfused rabbit hearts when used at concentrations ranging from 3 to 30 µM.4 (±)-Ibutilide (15 µg/kg, i.v.) increases the effective refractory period (ERP) of the left and right atrium in anesthetized pigs.5 It prevents rapid pacing-induced atrial flutter in dogs when administered orally at doses ranging from 0.25 to 5 mg/kg. Formulations containing ibutilide have been used in the treatment of atrial arrhythmias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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