A potent, selective BMP1 inhibitor
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UK 383367

Item No. 15029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(βR)-3-(aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
CAS Number
348622-88-8
Molecular Formula
C15H24N4O4
Formula Weight
324.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mLDMSO: 25 mg/mLDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mLEthanol: 16 mg/mL
SMILES
O=C(NO)C[C@@H](CCCC1CCCCC1)C2=NC(C(N)=O)=NO2
InChi Code
InChI=1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1
InChi Key
ARJCBSRIPGJMAD-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $70

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    10 mg

    $96

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    25 mg

    $190

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    Product Description

    UK 383367 is a potent inhibitor of bone morphogenetic protein 1 (BMP1; IC50 = 44 nM).1,2 It is more than 200-fold selective for BMP1 over a panel of matrix metalloproteinases. UK 383367 is effective in a cell-based model of collagen deposition is very effective at penetrating human skin in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fish, P.V., Allan, G.A., Bailey, S., et al. Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J. Med. Chem. 50915), 3442-3456 (2007).

    2. Bailey, S., Fish, P.V., Billotte, S., et al. Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg. Med. Chem. Lett. 18(24), 6562-6567 (2008).