An agonist of α7 and α4β2 nAChRs
Related Products
Metabolite(s)
22388Hydroxy Varenicline
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Varenicline (tartrate)

Item No. 15030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine-(2R,3R)-dihydroxybutanedioate
CAS Number
375815-87-5
Synonyms
  • CP 526,555-18
Molecular Formula
C13H13N3 • C4H6O6
Formula Weight
361.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: InsolubeDMSO: 5 mg/mlEthanol: InsolubePBS (pH 7.2): 10 mg/ml
λmax
204, 236, 320 nm
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.C12=CC3=C(N=CC=N3)C=C1C4CNCC2C4
InChi Code
InChI=1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)
InChi Key
TWYFGYXQSYOKLK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $117

    Add

    10 mg

    $218

    Add

    25 mg

    $514

    Add

    50 mg

    $909

    Add
    Product Description

    Varenicline is a full agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs; EC50 = 18 µM) and a partial agonist of α4β2 subunit-containing nAChRs (EC50 = 2.3 µM).1 Formulations containing varenicline have been used as aids in smoking cessation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mihalak, K.B., Carroll, F.I., and Luetje, C.W. Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors. Mol. Pharm. 70(3), 801-805 (2006).