An agonist of α7 and α4β2 nAChRs
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Metabolite(s)
22388Hydroxy Varenicline
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Varenicline (tartrate)

Item No. 15030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine-(2R,3R)-dihydroxybutanedioate
CAS Number
375815-87-5
Synonyms
  • CP 526,555-18
Molecular Formula
C13H13N3 • C4H6O6
Formula Weight
361.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: InsolubeDMSO: 5 mg/mlEthanol: InsolubePBS (pH 7.2): 10 mg/ml
λmax
204, 236, 320 nm
SMILES
O[C@H]([C@@H](O)C(O)=O)C(O)=O.C12=CC3=C(N=CC=N3)C=C1C4CNCC2C4
InChi Code
InChI=1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)
InChi Key
TWYFGYXQSYOKLK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $117

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    10 mg

    $218

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    25 mg

    $514

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    50 mg

    $909

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    Product Description

    Varenicline is a full agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs; EC50 = 18 µM) and a partial agonist of α4β2 subunit-containing nAChRs (EC50 = 2.3 µM).1 Formulations containing varenicline have been used as aids in smoking cessation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mihalak, K.B., Carroll, F.I., and Luetje, C.W. Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors. Mol. Pharm. 70(3), 801-805 (2006).