An antioxidant and hypocholesterolemic compound
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Probucol

Item No. 15043

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol
CAS Number
23288-49-5
Synonyms
  • DH 581
  • Lorelco
  • NSC 86225
  • NSC 652160
Molecular Formula
C31H48O2S2
Formula Weight
516.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/ml
λmax
207, 243 nm
SMILES
CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O
InChi Code
InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
InChi Key
FYPMFJGVHOHGLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Cayman Chemical
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    Product Description

    Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.1 Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.1 Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.2 In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamamoto, A. A uniqe antilipidemic drug--Probucol. J. Atheroscler. Thromb. 15(6), 304-305 (2013).

    2. Favari, E., Zanotti, I., Zimetti, F., et al. Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler. Thromb. Vasc. Biol. 24(12), 2345-2350 (2004).

    3. Colle, D., Santos, D.B., Moreira, E.L.G., et al. Probucol increases striatal glutathione peroxidase activity and protects against 3-nitropropionic acid-induced pro-oxidative damage in rats. PLoS One 8(6), e67658 (2013).