A selective inhibitor of MAO-B
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R-(−)-Deprenyl (hydrochloride)

Item No. 15046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-N,α-dimethyl-N-2-propyn-1-yl-benzeneethanamine, monohydrochloride
CAS Number
14611-52-0
Synonyms
  • L-Deprenyl
  • Selegiline
Molecular Formula
C13H17N • HCl
Formula Weight
223.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CN(CC#C)[C@H](C)CC1=CC=CC=C1.Cl
InChi Code
InChI=1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1
InChi Key
IYETZZCWLLUHIJ-UTONKHPSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $36

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    250 mg

    $66

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    500 mg

    $103

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    1 g

    $153

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    Product Description

    R-(−)-Deprenyl is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM).1,2 In addition to finding use against depression, R-(−)-deprenyl provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.3,4 The ability of this compound to slow the progression of disability in early Parkinson’s disease may be independent of its effects on MAO activity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jagrat, M., Behera, J., Yabanoglu, S., et al. Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studies. Bioorg. Med. Chem. Lett. 21(14), 4296-4300 (2011).

    2. La Regina, G., Silvestri, R., Gatti, V., et al. Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg. Med. Chem. 16(22), 9729-9740 (2008).

    3. Hara, M.R., Thomas, B., Cascio, M.B., et al. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc. Natl. Acad. Sci. USA 103(10), 3887-3889 (2006).

    4. Wimbiscus, M., Kostenko, O., and Malone, D. MAO inhibitors: Risks, benefits, and lore. Cleve. Clin. J. Med. 77(12), 859-882 (2010).