An inhibitor of N-WASP
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Wiskostatin

Item No. 15047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,6-dibromo-α-[(dimethylamino)methyl]-9H-carbazole-9-ethanol
CAS Number
253449-04-6
Molecular Formula
C17H18Br2N2O
Formula Weight
426.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 20 mg/mlEthanol: 0.25 mg/ml
λmax
234, 241, 271, 303, 344, 359 nm
SMILES
OC(CN(C)C)CN1C2=CC=C(Br)C=C2C3=C1C=CC(Br)=C3
InChi Code
InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
InChi Key
XUBJEDZHBUPBKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $128

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    10 mg

    $172

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    50 mg

    $662

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    Product Description

    Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 μM).1 It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate.1 By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peterson, J.R., Bickford, L.C., Morgan, D., et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat. Struct. Mol. Biol. 11(8), 747-755 (2004).

    2. Guerriero, C.J., and Weisz, O.A. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am. J. Physiol. Cell Physiol. 292(4), C1562-C1566 (2007).

    3. Welliver, T.P., Chang, S.L., Linderman, J.J., et al. Ruffles limit diffusion in the plasma membrane during macropinosome formation. J. Cell Sci. 124(23), 4106-4114 (2011).

    4. Wegner, A.M., Nebhan, C.A., Hu, L., et al. N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. The Journal of Biological Chemisty 283(23), 15912-15920 (2008).