A selective dopamine D1-like receptor agonist
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(±)-SKF 81297 (hydrobromide)

Item No. 15067

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol, monohydrobromide
CAS Number
67287-39-2
Synonyms
  • (±)-6-chloro-PB
Molecular Formula
C16H16ClNO2 • HBr
Formula Weight
370.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.04 mg/mlEthanol: 2 mg/ml
SMILES
OC1=CC2=C(C(Cl)=C1O)CCNCC2C3=CC=CC=C3.Br
InChi Code
InChI=1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
InChi Key
RMIJGBMRNYUZRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

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    25 mg

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    Product Description

    (±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM).1 It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).1 Activation of dopamine D1-like receptors by selective agonists such as (±)-SKF 81297 have been implicated in initiating a cascade of signaling events leading to reward-related incentive learning.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neumeyer, J.L., Kula, N.S., Bergman, J., et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur. J. Pharmacol. 474(2-3), 137-140 (2003).

    2. Beninger, R.J., and Miller, R. Dopamine D1-like receptors and reward-related incentive learning. Neurosci. Biobehav. Rev. 22(2), 335-345 (1998).