A furanocoumarin with anti-cancer activity
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Psoralidin

Item No. 15119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,9-dihydroxy-2-(3-methyl-2-buten-1-yl)-6H-benzofuro[3,2-c][1]benzopyran-6-one
CAS Number
18642-23-4
Molecular Formula
C20H16O5
Formula Weight
336.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 14 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
λmax
243, 306, 347 nm
SMILES
OC1=CC(O2)=C(C=C1)C3=C2C4=C(OC3=O)C=C(O)C(C/C=C(C)/C)=C4
InChi Code
InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3
InChi Key
YABIJLLNNFURIJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $148

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    25 mg

    $281

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    100 mg

    $783

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    Cayman Chemical
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    Product Description

    Psoralidin is a furanocoumarin isolated from the seeds of P. corylifolia, a medicinal plant found in southeastern Asia, that has been shown to induce cytotoxicity against various cancer cells.1 Through TNF-related apoptosis-inducing ligand-mediated events, psoralidin at 50 μM can induce the death of HeLa cancer cells.2 It also can induce apoptosis of androgen-dependent (LNCaP, C4-2B) and androgen-independent (DU-145, PC-3) prostate cancer cells and inhibit the growth of PC-3 xenograft tumors in nude mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pahari, P., and Rohr, J. Total synthesis of psoralidin, an anticancer natural product. The Journal of Organic Chemistry 74(7), 2750-2754 (2009).

    2. Bronikowska, J., Szliszka, E., Jaworska, D., et al. The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Molecules 17(6), 6449-6464 (2012).

    3. Kumar, R., Srinivasan, S., Pahari, P., et al. Activating SAPK-mediated cell death and inhibiting EGFR signaling: A promising therapeutic strategy for prostate cancer. Mol. Cancer Ther. 9(9), 2488-2496 (2010).