An inhibitor of choline acetyltransferase
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α-NETA

Item No. 15125

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide
CAS Number
31059-54-8
Molecular Formula
C16H20NO • I
Formula Weight
369.2
Purity
≥97%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 3mg/mlMethanol: Soluble
SMILES
O=C(CC[N+](C)(C)C)C1=CC2=CC=CC=C2C=C1.[I-]
InChi Code
InChI=1S/C16H20NO.HI/c1-17(2,3)11-10-16(18)15-9-8-13-6-4-5-7-14(13)12-15;/h4-9,12H,10-11H2,1-3H3;1H/q+1;/p-1
InChi Key
LIFHUGCXEAQKRZ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    25 mg

    $178

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    Product Description

    α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM).1,2 This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase.2 α-NETA is commonly used in cells in culture.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sastry, B.V., Jaiswal, N., Owens, L.K., et al. 2-(α-Naphthoyl)ethyltrimethylammonium iodide and its β-isomer: New selective, stable and fluorescent inhibitors of choline acetyltransferase. J. Pharmacol. Exp. Ther. 245(1), 72-80 (1988).

    2. Sastry, B.V., Jaiswal, N., Janson, V., et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol. Res. Commun. 20(9), 751-771 (1988).

    3. Eaton, B.M., and Sooranna, S.R. Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells. Placenta 19(8), 663-669 (1998).

    4. Sawatzky, D.A., Kingham, P.J., Durcan, N., et al. Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 285(6), L1296-L1304 (2003).