A fluorescent probe for zinc
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Zinquin ethyl ester

Item No. 15133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-acetic acid, ethyl ester
CAS Number
181530-09-6
Molecular Formula
C21H22N2O5S
Formula Weight
414.5
Purity
≥98%
Emission
490 nm
Excitation
368 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 0.5 mg/ml
λmax
212, 244, 336 nm
SMILES
CC1=CC=C(S(NC2=C(N=C(C)C=C3)C3=CC(OCC(OCC)=O)=C2)(=O)=O)C=C1
InChi Code
InChI=1S/C21H22N2O5S/c1-4-27-20(24)13-28-17-11-16-8-7-15(3)22-21(16)19(12-17)23-29(25,26)18-9-5-14(2)6-10-18/h5-12,23H,4,13H2,1-3H3
InChi Key
KCASTCXJTDRDFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $86

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    5 mg

    $190

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    10 mg

    $329

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    Product Description

    Zinquin ethyl ester is a cell-permeable, quinolone-based fluorescent probe used as a zinc indicator.1 In live cells, cytosolic esterases cleave the ethyl ester group preventing its efflux across the plasma membrane.2 This probe is UV-excitable and emits in the blue region of the spectrum (excitation 368 nm, emission 490 nm).2 Zinquin ethyl ester has been used to monitor intracellular zinc fluxes associated with apoptosis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sabnis, R.W. Handbook of biological dyes and stains: Synthesis and industrial applications. (2010).

    2. Nowakowski, A.B., and Petering, D.H. Reactions of the fluorescent sensor, zinquin, with the zinc-proteome: Adduct formation and ligand substitution. Inorg. Chem. 50(20), 10124-10133 (2011).

    3. Helmersson, A., von Arnold, S., and Bozhkov, P.V. The level of free intracellular zinc mediates programmed cell death/cell survival decisions in plant embryos. Plant Physiol. 147(3), 1158-1167 (2008).