A clickable form of puromycin
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O-Propargyl-puromycin

Item No. 15134

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3'-[[(2S)-2-amino-1-oxo-3-[4-(2-propyn-1-yloxy)phenyl]propyl]amino]-3'-deoxy-N,N-dimethyl-adenosine
CAS Number
1416561-90-4
Synonyms
  • Click TagTM O-Propargyl-puromycin
  • OPP
  • OP-puro
Molecular Formula
C24H29N7O5
Formula Weight
495.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: soluble
λmax
217, 275 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N(C)C)O[C@H](CO)[C@H]1NC([C@@H](N)CC4=CC=C(OCC#C)C=C4)=O
InChi Code
InChI=1S/C24H29N7O5/c1-4-9-35-15-7-5-14(6-8-15)10-16(25)23(34)29-18-17(11-32)36-24(20(18)33)31-13-28-19-21(30(2)3)26-12-27-22(19)31/h1,5-8,12-13,16-18,20,24,32-33H,9-11,25H2,2-3H3,(H,29,34)/t16-,17+,18+,20+,24+/m0/s1
InChi Key
JXBIGWQNNSJLQK-IYRMOJGWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $208

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    1 mg

    $374

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    Product Description

    O-Propargyl-puromycin (OP-puro) is a clickable form of the protein synthesis inhibitor puromycin (Item No. 13884).1 It inhibits protein synthesis in rabbit reticulocyte lysates and HEK293T cells when used at concentrations ranging from 1 to 25 µM. OP-puro is incorporated into nascent polypeptide chains where it forms covalent adducts and terminates chain elongation on the ribosome. It has been used in combination with fluorescent azides to image nascent proteins in various cells.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Xu, Y., Stoleru, D., et al. Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc. Natl. Acad. Sci. USA 109(2), 413-418 (2012).

    2. Forester, C.M., Zhao, Q., Phillips, N.J., et al. Revealing nascent proteomics in signaling pathways and cell differentiation. Proc. Natl. Acad. Sci. USA 115(10), 2353-2358 (2018).