A pan-caspase inhibitor
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Z-Asp-CH2-DCB

Item No. 15143

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester 2,6-dichloro-benzoic acid
CAS Number
153088-73-4
Synonyms
  • Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone
Molecular Formula
C20H17Cl2NO7
Formula Weight
454.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 33 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
ClC1=C(C(OCC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(O)=O)=O)=O)C(Cl)=CC=C1
InChi Code
InChI=1S/C20H17Cl2NO7/c21-13-7-4-8-14(22)18(13)19(27)29-11-16(24)15(9-17(25)26)23-20(28)30-10-12-5-2-1-3-6-12/h1-8,15H,9-11H2,(H,23,28)(H,25,26)/t15-/m0/s1
InChi Key
FKJMFCOMZYPWCO-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3.1,2 Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity.2 At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dolle, R.E., Hoyer, D., Prasad, C.V.C., et al. P1 aspartate-based peptide α-((2,6dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1β-converting enzyme. J. Med. Chem. 37(5), 563-564 (1994).

    2. Mashima, T., Naito, M., Kataoka, S., et al. Aspartate-based inhibitor of interleukin-1-β-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells. Biochem. Biophys. Res. Commun. 209(3), 907-915 (1995).

    3. Krakauer, T. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin. Diagn. Lab. Immunol. 11(3), 621-624 (2004).