A respiratory chain inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

HQNO

Item No. 15159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-heptyl-4-quinolinol 1-oxide
CAS Number
341-88-8
Synonyms
  • KF8940
  • N-oxo-2-heptyl-4-Hydroxyquinoline
  • Pyo II
Molecular Formula
C16H21NO2
Formula Weight
259.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 1 mg/mlEthanol: 3 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
214, 242, 330 nm
SMILES
[O-][N+]1=C(CCCCCCC)C=C(O)C2=CC=CC=C21
InChi Code
InChI=1S/C16H21NO2/c1-2-3-4-5-6-9-13-12-16(18)14-10-7-8-11-15(14)17(13)19/h7-8,10-12,18H,2-6,9H2,1H3
InChi Key
NZPACTGCRWDXCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $75

    Add

    10 mg

    $128

    Add

    50 mg

    $479

    Add
    Product Description

    HQNO is an inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein, a component of complex III.1 In Vibrio alginolyticus, HQNO blocks 90% the activity of the sodium transporting NADH oxidase at a concentration of 40 μM.2 It is a useful tool for probing the mechanisms of electron transfer and proton or sodium translocation by the respiratory chain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Ark, G., and Berden, J.A. Binding of HQNO to beef-heart sub-mitochondrial particles. Biochim. Biophys. Acta 459(1), 119-127 (1977).

    2. Tokuda, H., and Unemoto, T. Na+ is translocated at NADH:quinone oxidoreductase segment in the respiratory chain of Vibrio alginolyticus. The Journal of Biological Chemisty 259(12), 7785-7790 (1984).