A selective inhibitor of PDE4A
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ML-030

Item No. 15169

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
CAS Number
1013750-77-0
Synonyms
  • CID-11757146
Molecular Formula
C20H20N4O4S
Formula Weight
412.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
324 nm
SMILES
COC1=C(OC)C=CC(C(CS2)=NN3C2=NN=C3C4=C(OC)C=CC(OC)=C4)=C1
InChi Code
InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3
InChi Key
DZAUSKKPHXFGNN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $213

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    25 mg

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    Product Description

    ML-030 is a triazolothiadiazine that inhibits PDE4 in a cell-based cyclic nucleotide-gated cation channel biosensor assay with an EC50 value of 18.7 nM.1,2 Among the PDE4 isoforms, ML-030 displays selectivity for inhibiting PDE4A (IC50 = 6.7 nM) over PDE4B1, PDE4B2, PDE4C1, and PDE4D2 (IC50 = 48.2, 37.2, 452, and 49.2 nM, respectively).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Skoumbourdis, A.P., Huang, R., Southall, N., et al. Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorg. Med. Chem. Lett. 18(4), 1297-1303 (2008).

    2. Skoumbourdis, A.P., LeClair, C.A., Stefan, E., et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg. Med. Chem. Lett. 19(13), 3686-3692 (2009).