A selective NOX1 inhibitor
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ML-090

Item No. 15172

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,12-dihydro-quinoxalino[2,3-b]quinoxaline
CAS Number
531-46-4
Synonyms
  • CCG-44699
  • CID-616479
  • Fluoflavin
  • NSC 179821
Molecular Formula
C14H10N4
Formula Weight
234.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly SolubleDMF: Slightly SolubleDMSO: Slightly SolubleEthanol: Slightly Soluble
λmax
248, 324, 341, 393, 415, 442 nm
SMILES
C12=CC=CC=C1N=C3C(NC(C=CC=C4)=C4N3)=N2
InChi Code
InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)
InChi Key
WGKYYZDYHYOKQV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $77

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    50 mg

    $128

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    Product Description

    NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer.1 ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 µM) and xanthine oxidase (IC50 = 3.5 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, S.J., Gianni, D., Bokoch, G., et al. Probe report for NOX1 inhibitors. Probe Reports from the NIH Molecular Libraries Program 1-7 (2010).