A PLAP inhibitor
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors
Phosphatases

Research Area

ML-095 (hydrochloride)

Item No. 15173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3,4-dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-ethanone, monohydrochloride
CAS Number
1135318-57-8
Synonyms
  • CID-25067483
Molecular Formula
C13H14N2O3 • HCl
Formula Weight
282.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
235, 283, 316 nm
SMILES
OC1=CC=C(C(CN2C=CN=C2CC)=O)C=C1O.Cl
InChi Code
InChI=1S/C13H14N2O3.ClH/c1-2-13-14-5-6-15(13)8-12(18)9-3-4-10(16)11(17)7-9;/h3-7,16-17H,2,8H2,1H3;1H
InChi Key
VTSPJLHFXSMCCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $213

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    25 mg

    $412

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    Product Description

    Alkaline phosphatases catalyze the hydrolysis of phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. Three isozymes of alkaline phosphatases have been identified in humans, two of which are tissue-specific placental alkaline phosphatase (PLAP), intestinal alkaline phosphatase (IAP), and tissue non-specific alkaline phosphatase (TNAP). While the biological function of PLAP is unknown, PLAP-like enzymes have been detected in the serum of patients with primary testicular tumors and other cancers.1 ML-095 is an inhibitor of PLAP (IC50 = 3.7 μM) that demonstrates high selectivity against the related alkaline phosphatases, TNAP and IAP (IC50s > 100 μM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lanier, M., Cashman, J., Sergienko, E., et al. Placental alkaline phosphatase (PLAP) luminescent HTS assay. 2, 1-11 (2009).