A cell-permeable STAT3 activator
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ML-115

Item No. 15178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide
CAS Number
912798-42-6
Synonyms
  • CID-6619100
  • SID 14735210
Molecular Formula
C15H15ClN2O4
Formula Weight
322.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 16 mg/mlEthanol: 0.1 mg/ml
λmax
236, 317 nm
SMILES
COC1=CC(NC(C2=NOC(C3CC3)=C2)=O)=C(OC)C=C1Cl
InChi Code
InChI=1S/C15H15ClN2O4/c1-20-13-6-10(14(21-2)5-9(13)16)17-15(19)11-7-12(22-18-11)8-3-4-8/h5-8H,3-4H2,1-2H3,(H,17,19)
InChi Key
FMWABCRYNLCXOJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $54

    Add

    1 mg

    $102

    Add

    5 mg

    $392

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    ML-115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB.1 It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML-115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6.1 As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML-115 may be useful in maintaining embryonic stem cells in an undifferentiated state.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Madoux, F., Koenig, M., Nelson, E., et al. Modulators of STAT transcription factors for the targeted therapy of cancer (STAT3 activators). (2009).