Reversible inhibitor of PAR1-mediated platelet activation
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ML-161

Item No. 15179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide
CAS Number
423735-93-7
Synonyms
  • AG-670
  • CID-1048267
Molecular Formula
C17H17BrN2O2
Formula Weight
361.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
240 nm
SMILES
BrC1=C(C(NC2=CC=CC(NC(CCC)=O)=C2)=O)C=CC=C1
InChi Code
InChI=1S/C17H17BrN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22)
InChi Key
DFOVLSMXPWPCFH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $169

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    25 mg

    $369

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    Product Description

    ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM.1 It blocks platelet activation induced by thrombin as well as by SFLLRN but not by PMA (Item No. 10008014), U-46619 (Item No. 16450), or collagen.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dockendorff, C., Aisiku, O., VerPlank, L., et al. Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med. Chem. Lett. 3(3), 232-237 (2012).