An inhibitor of the DNA repair enzyme Bloom helicase
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ML-216

Item No. 15186

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea
CAS Number
1430213-30-1
Synonyms
  • CID-49852229
Molecular Formula
C15H9F4N5OS
Formula Weight
383.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
λmax
242, 300 nm
SMILES
FC1=CC=C(NC(NC2=NN=C(C3=CC=NC=C3)S2)=O)C=C1C(F)(F)F
InChi Code
InChI=1S/C15H9F4N5OS/c16-11-2-1-9(7-10(11)15(17,18)19)21-13(25)22-14-24-23-12(26-14)8-3-5-20-6-4-8/h1-7H,(H2,21,22,24,25)
InChi Key
WMCOYUSJXXCHFH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $132

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    25 mg

    $294

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    Cayman Chemical
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    Product Description

    Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM).1 At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosenthal, A.S., Dexheimer, T.S., Nguyen, G., et al. Discovery of ML216, a small molecule inhibitor of bloom (BLM) helicase. 1-22 (2011).