An inhibitor of breast cancer stem cells
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ML-239

Item No. 15188

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
CAS Number
1378872-36-6
Synonyms
  • CID-49843203
Molecular Formula
C13H10Cl3N3O2
Formula Weight
346.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
314 nm
SMILES
O=C(COC1=C(Cl)C=C(Cl)C=C1Cl)N/N=C/C2=CC=CN2
InChi Code
InChI=1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
InChi Key
NVEDPFICKAIHKD-NGYBGAFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $90

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    10 mg

    $169

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    25 mg

    $336

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    Cayman Chemical
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    Product Description

    ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM).1,2,3 It is also toxic to the breast carcinoma cell line MDA-MB-231.1 ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways.1,3 It is stable in saline and modestly stable in human plasma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carmody, L.C., Germain, A.R., VerPlank, L., et al. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J. Biomol. Screen. 17(9), 1204-1210 (2012).

    2. Germain, A.R., Carmody, L.C., Morgan, B., et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg. Med. Chem. Lett. 22(10), 3571-3574 (2012).

    3. Carmody, L., Garmain, A., Morgan, B., et al. Identification of a selective small-molecule inhibitor of breast cancer stem cells - Probe 1. 1, 1-13 (2011).